解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The 1,3-dipolar cycloaddition of azomethine ylide derived in situ from the reaction of acenaphthylene-1,2-dione and 1,3-thiazolane-4-carboxylic acid to various exocyclic dipolarophiles synthesized from trans-androsterone and trans-dehydroandrosterone afforded a library of novel spiro[5'.2″]acenaphthylene-1″-one-spiro[...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.12.017
更新日期:2013-04-01 00:00:00
abstract::Aldosterone induces fibrotic changes in cardiovascular tissues but its effects have usually been demonstrated in models of pre-existing renal injury and/or hypertension. This study tests the hypothesis that aldosterone can directly induce vascular fibrotic changes in the absence of prior renal injury or hypertension. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.12.007
更新日期:2013-03-01 00:00:00
abstract::Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.10.015
更新日期:2013-02-01 00:00:00
abstract::Glucocorticoids are important regulators of metabolism and immune function. Synthetic glucocorticoids are extensively used for immunosuppression/anti-inflammatory therapy. Since the glucocorticoid receptor (GR) is central to most hormone effects; its in vivo regulation will influence hormone/drug action. An alternativ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.11.014
更新日期:2013-02-01 00:00:00
abstract::Nine new steroidal glycosides, named as stauntosides C-K (2, 5, 7-10, 13, 14, and 16), along with seven known compounds (1, 3, 4, 6, 11, 12, and 15) were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. The structures of these new compounds were elucidated on the basis of extensive spectrosc...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.10.007
更新日期:2013-01-01 00:00:00
abstract::Three new polyhydroxysterols, named muriflasteroids A-C (1-3) were isolated from the South China Sea gorgonian Muriceopsis flavida, together with sixteen known analogs, cholest-3β,5α,6β-triol,3β-acetate (4), 5α-methoxycholest-3β,6β-diol (5), (22E)-cholest-22-en-3β,5α,6β-triol (6), cholest-3β,5α,6β-triol (7), (22E)-24-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.10.003
更新日期:2013-01-01 00:00:00
abstract::The steroid nucleus is an interesting scaffold for the development of new therapeutic agents. Within the goal of identifying anticancer agents, new pregnane derivatives were prepared by using a sequence of liquid and solid-phase reactions. After we dehydrated epi-allopregnanolone in one step with diethylaminosulfur tr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.07.012
更新日期:2012-11-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) reduces body fat in rodents and humans, and increases glycerol release from isolated rat epididymal adipocytes and human visceral adipose tissue explants. It suggests that DHEA stimulates triglyceride hydrolysis in adipose tissue; however, the mechanisms underlying this action are still u...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.08.002
更新日期:2012-11-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.08.005
更新日期:2012-11-01 00:00:00
abstract::The accurate analysis of trace components in complex biological matrices requires the use of reliable internal standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled analogues of the analyte molecules are the most appropriate internal standards. In this paper the synthesis of the 3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.08.007
更新日期:2012-11-01 00:00:00
abstract::Starting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51Å for the edge O-O distance), and the knowledge that this value also corresponds to the O7-O12 distance of the skeleton of cholic acid, it is hypothesized that two ster...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::Progesterone and its polar metabolite(s) trigger the meiotic divisions in the amphibian oocyte through a non-genomic signaling system at the plasma membrane. Published site-directed mutagenesis studies of ouabain binding and progesterone-ouabain competition studies indicate that progesterone binds to a 23 amino acid e...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.04.012
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Once a septic condition is progressing, administration of steroids in the pro-inflammatory phase of septic shock ought to yield maximal effect on the subsequent, devastating inflammatory response. Recently, a retrospective study showed that early initiation of corticosteroid therapy improved survival in sept...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.06.001
更新日期:2012-09-01 00:00:00
abstract::We have previously demonstrated that 1α,25 dihydroxy-vitamin D(3) (1α,25(OH)(2)D(3)) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR). In this work, we have investigated whether 1α,25(OH)(2)D(3) exerts its growth i...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.05.006
更新日期:2012-09-01 00:00:00
abstract::Desoxymethyltestosterone (DMT; 17β-hydroxy-17α-methyl-5α-androst-2-ene) is a designer steroid present in hormonal supplements distributed illegally as such or in combination with other steroids, for self-administration. It figures on the list of substances prohibited in sports and its detection in athlete's urine samp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.02.008
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Estrogen replacement therapy increases risk for ovarian epithelial cancer, a cancer of mainly older women, yet the response of older ovarian surface epithelium (OSE) to repeat estrogen exposure overtime has not been studied. We have previously reported significant reductions in estrogen receptor (ER) protein...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.02.015
更新日期:2012-05-01 00:00:00
abstract::Phytochemical characterization of a commercial herb sample supplied as Smilax ornata Lem. (sarsaparilla) led to the isolation of five steroidal saponins, including two new furostanol saponins sarsaparilloside B (1) and sarsaparilloside C (2), whose structures were elucidated via a combination of multistage mass spectr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.01.009
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) is mainly defined by hyperandrogenemia, from ovarian and adrenal origin, and is characterized by insulin resistance (IR). Studies found that raising in vivo non-esterified fatty acid (NEFA) levels, which induces lipotoxicity, increases androgen levels and IR. The aim of this ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.12.017
更新日期:2012-03-10 00:00:00
abstract::Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.11.010
更新日期:2012-02-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals. DHEA can be converted to multiple oxygenated metabolites in the brain and peripheral tissues. The mechanisms by which DHEA exerts its effects are not well understood. However, evidence that the ef...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2011.09.008
更新日期:2012-01-01 00:00:00
abstract::Although exogenous glucocorticoids (GC) play a role in the regulation of bone marrow mesenchymal stem/stromal cells (MSCs) proliferation and differentiation, the function of endogenous GC is not well understood. The purpose of this study was to investigate the effect of the blockage of endogenous GC using RU486, an an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.10.017
更新日期:2012-01-01 00:00:00
abstract::This paper revealed the expression pattern of ERα in the ovoviviparous teleost, Sebastes schlegeli. In this paper, we isolated the cDNA encoding for estrogen receptor alpha of black rockfish (S. schlegeli) from its ovary, named as black rockfish ERα (brfERα). The cDNA sequence of brfERα consists of 2972bp with an open...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.09.014
更新日期:2011-12-20 00:00:00
abstract:OBJECTIVE:To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. EXPERIMENTAL:We evaluated 30 young (27±1 year) premenopausal, non-obese (23±0.5 kg/m(2)), normally...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.06.001
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.06.004
更新日期:2011-11-01 00:00:00
abstract::The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.05.003
更新日期:2011-09-01 00:00:00
abstract::We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.05.009
更新日期:2011-09-01 00:00:00
abstract::Inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) regulate the activity of the hypothalamo-pituitary-adrenal (HPA) axis at several levels. Although hypothalamic CRH secretion may be the primary mechanism by which these cytokines activate the HPA axis, IL-1 expression is increased within t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.04.018
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder due to mutation in the CYP21A2 gene. OBJECTIVE:To elucidate the genetic basis of 21-hydroxylase-deficient CAH in Hong Kong Chinese patients. PATIENTS AND METHODS:Mutational analysis of the CY...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.04.010
更新日期:2011-09-01 00:00:00
abstract::By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first penta...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.04.003
更新日期:2011-09-01 00:00:00
abstract::The therapeutic use of progesterone following traumatic brain injury has recently entered phase III clinical trials as a means of neuroprotection. Although it has been hypothesized that progesterone protects against calcium overload following excitotoxic shock, the exact mechanisms underlying the beneficial effects of...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.013
更新日期:2011-08-01 00:00:00
abstract::Estrogen receptor (ER) positive primary breast cancers have a wide range of clinical outcomes. Prediction of the likely course of the disease aids treatment decision-making. In the translational arm of the ATAC (anastrozole or tamoxifen alone or combined) trial (TransATAC) we have assessed individual and multiparamete...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.032
更新日期:2011-07-01 00:00:00
abstract::Aromatase (CYP19A1) is an integral membrane enzyme that catalyzes the removal of the 19-methyl group and aromatization of the A-ring of androgens. All human estrogens are synthesized from their androgenic precursors by this unique cytochrome P450. The crystal structure of active aromatase purified from human placenta ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.030
更新日期:2011-07-01 00:00:00
abstract::Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.029
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Although systemic, topical, and periocular corticosteroid administration have long been associated with ocular side effects, there has been little evidence to suggest that long-term inhaled corticosteroids can cause ocular side effects. The aim of this study was to evaluate the effects of long term treatment ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.003
更新日期:2011-05-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.006
更新日期:2011-05-01 00:00:00
abstract::A short and efficient synthesis of steroid synthons, di(tert-butyldimethylsilyl) ethers of 3,21-dihydroxy-24-nor-chol-5-en-23-al (8 and 10) and of ethyl 3,21-dihydroxy-25-homo-chola-5,23-dien-25-oate (9 and 11), having natural (20R) and unnatural (20S) configuration from 3β-(tert-butyldimethylsilyloxy)-14α,20ξ-card-5-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.01.010
更新日期:2011-04-01 00:00:00
abstract::The steroid hormone dehydroepiandrosterone (DHEA) has beneficial effects on vascular function, survival of neurons, and fatty acid metabolism. However, a specific receptor for DHEA has not been identified to date. Here, we describe the synthesis of a photoreactive DHEA derivative (Photo-DHEA). In Photo-DHEA, typical c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.01.009
更新日期:2011-04-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA) fatty acyl esters once incorporated in high density lipoprotein (HDL) induce a stronger vasodilatory response in rat mesenteric arteries ex vivo compared to native HDL. We studied the role of HDL receptor, scavenger receptor class B, type 1 (SR-B1), as well as estrogen and androgen recept...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.12.007
更新日期:2011-03-01 00:00:00
abstract::Estradiol benzoate (EB) has been one of the most widely used estrogenic agents in animal husbandry, as a way of exogenously introducing the natural hormone estradiol-17β into the animal organism. Estradiol was previously employed to induce anabolic effects or reproductive improvements in cattle. However, the employmen...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.12.005
更新日期:2011-03-01 00:00:00
abstract::The mechanism accounting for the development of castration-resistant prostate cancer (CRPC) remains unclear. Studies in CRPC tissues suggest that, after androgen deprivation therapy (ADT), the adrenal androgens may be an important source of testosterone (T) and 5-alpha dihydrotestosterone (DHT) in CRPC tissues. To cla...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.12.001
更新日期:2011-02-01 00:00:00